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Senior Honors Projects, 2010-2019
Title
Author
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Cerebral Invasion Mac Os Download
Date of Graduation
Cerebral Invasion Mac Os Catalina
Spring 2016
Document Type
Thesis
Degree Name
Bachelor of Science (BS)
Department
Department of Biology
Advisor(s)
Chris Lantz
Abstract
Malaria is a life-threatening mosquito-borne disease caused by parasites of the genus Plasmodium, with about 200 million new cases reported each year. In rodent models of malaria, a variety of immune proteins called cytokines have been noted to either promote or suppress protective immunity. While the cytokine interleukin-3 (IL-3) clearly promotes host defense against some intestinal nematode parasites, few studies have reported a similar function for IL-3 in the pathophysiology of malaria. In this study, we investigated the role of IL-3 in a mouse model of cerebral malaria caused by Plasmodium berghei ANKA. We infected wild-type (WT) and IL-3 deficient (IL-3 KO) mice with P. berghei ANKA and characterized parameters indicative of a protective host response to infection. We found that male IL-3 KO mice generally survived longer than corresponding WT mice, although no differences between blood parasitemia or hematocrit levels were observed between the two genotypes. In addition, male IL-3 KO mice had an increased splenomegaly, and at day 6 p.i. All i wanted was to make a game mac os. showed less vascular damage in the brain than did corresponding infected WT mice. These findings suggest that IL-3 plays a role in suppressing protective immunity in a mouse model of cerebral malaria.
Recommended Citation
Perry, Brendon R., 'Role of interleukin-3 in an experimental model of mouse cerebral malaria caused by Plasmodium berghei ANKA' (2016). Senior Honors Projects, 2010-2019. 141.
https://commons.lib.jmu.edu/honors201019/141
Included in
Animal Diseases Commons, Immune System Diseases Commons, Parasitic Diseases Commons, Pathological Conditions, Signs and Symptoms Commons
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